What is the clinical evidence from this study?

Study design: Meta-Analysis. Population: Obstructive Sleep Apnea (OSA) (n=269). Intervention: Continuous Positive Airway Pressure (CPAP) vs. Baseline (pre-treatment). Primary outcome: Carotid intima-media thickness (CIMT) (MD 0.08, 95% CI 0.04, 0.13, p=<0.05).

January 1, 2025Open Access

The Effect of CPAP Treatment on Carotid Intima-Media Thickness in Patients with OSA: A Meta-Analysis

Q: What are the key findings of this study?

Continuous positive airway pressure (CPAP) therapy significantly reduced carotid intima-media thickness in patients with obstructive sleep apnea (MD 0.08, 95% CI 0.04-0.13, P < 0.05).

Q: What does this research mean for the field?

Continuous positive airway pressure (CPAP) therapy significantly reduces carotid intima-media thickness in patients with obstructive sleep apnea. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

翔李翔李

Key Result

Continuous positive airway pressure (CPAP) therapy significantly reduced carotid intima-media thickness in patients with obstructive sleep apnea (MD 0.08, 95% CI 0.04-0.13, P < 0.05).

Study Design

Type

Meta-Analysis (n=269)

Structured PICO

Does continuous positive airway pressure (CPAP) therapy reduce carotid intima-media thickness in adult patients with obstructive sleep apnea?

Population

269 adult patients with obstructive sleep apnea from 8 studies, evaluated for changes in carotid intima-media thickness before and after 3 to 12 months of CPAP therapy.

Intervention

Continuous positive airway pressure (CPAP) therapy (treatment duration ranging from 3 to 12 months).

Comparator

Baseline (pre-treatment carotid intima-media thickness values).

Outcome

Carotid intima-media thickness (CIMT) measured by ultrasound.surrogate

CPAP therapy effectively reduces carotid intima-media thickness in patients with obstructive sleep apnea, suggesting a potential benefit in delaying early atherosclerosis progression.

Main Result

Mean Difference: 0.08 (95% CI 0.04–0.13)

p-value: p=<0.05

Limitations

Significant heterogeneity among included studies without a clear source.
Potential publication bias due to the small number of included studies and small sample sizes.
Most included studies were single-center observational studies, lacking high-quality large randomized controlled trials.

Abstract

目的：探究持续气道正压通气(continuous positive airway pressure, CPAP)治疗对阻塞性睡眠呼吸暂停(obstructive sleep apnea, OSA)患者颈动脉内膜中层厚度(carotid intima-media thicknes, CIMT)的影响。方法：检索中国知网、万方、维普、中国生物医学文献、PubMed、The Cochrance Library、EMbase数据库，Web of Science数据库，时间截止至2024年8月。将符合标准的研究纳入，通过RevMan5.3软件进行统计分析。结果：共纳入8篇文献，共269例患者。Meta分析结果提示CPAP治疗前后的CIMT差异有统计学意义(MD = 0.08, 95% CI 0.04, 0.13, P Objective: To identify the effect of continuous positive airway pressure (CPAP) on carotid intima-media thickness (CIMT) in patients with obstructive sleep apnea (OSA). Methods: Eligible studies were retrieved from the CNKI, Wanfang, VIP, Chinese Biomedical Literature Database (CBM), PubMed, The Cochrane Library, EMbase, and Web of Science from the establishment of the database to August 2024. RevMan 5.3 software was used for analysis. Results: A total of 8 studies involving 269 patients were included. Meta-analysis results demonstrated a statistically significant difference in CIMT before and after CPAP (MD = 0.08, 95% CI 0.04, 0.13, P < 0.05), indicating a significant reduction in CIMT following CPAP therapy. Conclusion: CPAP therapy effectively reduces CIMT in OSA patients. However, high-quality randomized controlled trials (RCTs) are required to strengthen the evidence in the future.

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