June 5, 2025

Buprenorphine for Cancer Pain—The Safest Opioid, and Patients With Cancer Cannot Get It

ACAmy A. CaseRoswell Park Comprehensive Cancer Center MDMellar P. DavisLevine Cancer Institute MCMarcin ChwistekFox Chase Cancer Center

Key Points

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Abstract

This Viewpoint discusses the use of buprenorphine to treat cancer pain and difficulties in affordability and access despite its efficacy and safety compared with full-agonist opioids.

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Case et al. (Thu,) studied this question.

synapsesocial.com/papers/69dc694424e766dc3135925f https://doi.org/https://doi.org/10.1001/jamaoncol.2025.1337

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Opioid addiction, diversion, and abuse in chronic and cancer pain2018 · 22 citations
2Treating Chronic Pain with Buprenorphine—The Practical Guide2021 · 37 citations
3Factors associated with the development of depression in chronic non-cancer pain patients following the onset of opioid treatment for pain2015 · 42 citations
4Opioid addiction and misuse in adult and adolescent patients with cancer2017 · 40 citations
5Buprenorphine Use in Palliative Care2019 · 10 citations

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