Figure S3 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression | Synapse
Figure S3 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression
Key Points
Apolipoprotein E increases the tumor-stroma ratio in pancreatic neuroendocrine tumors.
This secretion leads to a richer stroma, which is associated with enhanced tumor progression.
Endothelial cells are induced by apoE to remodel the tumor environment.
Understanding these mechanisms can inform strategies targeting the tumor microenvironment in cancer therapy.
Abstract
ApoE promoted a stroma-rich microenvironment and tumor progression.