Figure S2 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression | Synapse
Figure S2 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression
Key Points
MAIN FINDING: Tumor-derived apolipoprotein E promotes tip endothelial cells crucial for tumor progression.
KEY EVIDENCE: Analysis reveals increased remodeling of tumor-stroma ratio linked to apolipoprotein E activity.
APPROACH: The work examines the effects of apolipoprotein E on specific endothelial cell subtypes in pancreatic cancer.
SIGNIFICANCE: This research highlights a key mechanism in cancer progression that could inform therapeutic strategies.
Abstract
Tumor-derived ApoE promoted a subtype of ECs, TipECs