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Table S9 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma | Synapse
August 2, 2025
Table S9 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma
LP
Lilian A. Patrón
SilaGene (United States)
HY
Helen Yeoman
SilaGene (United States)
JR
Joseph Ramos
The University of Texas Health Science Center at San Antonio
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Key Points
MAIN FINDING: RGN6024 demonstrates potential as a small-molecule tubulin destabilizer for glioblastoma treatment.
KEY EVIDENCE: Tests reveal enhanced cellular permeability of RGN6024 in brain tissues.
APPROACH: The study analyzes the effects of RGN6024 on tubulin dynamics in glioblastoma models.
SIGNIFICANCE: This research may open new pathways for therapeutic strategies against aggressive brain tumors.
Abstract
Cellular permeability of RGN6024
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Patrón et al. (Fri,) studied this question.
synapsesocial.com/papers/689a0c72e6551bb0af8d013c
https://doi.org/https://doi.org/10.1158/1535-7163.29761884
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