Figure S4 from Single-Cell Analysis of Posttranslational Modifications Identifies Immunosuppressive Macrophage Subtypes in the HBV-Positive Hepatocellular Carcinoma Microenvironment | Synapse
August 2, 2025
Figure S4 from Single-Cell Analysis of Posttranslational Modifications Identifies Immunosuppressive Macrophage Subtypes in the HBV-Positive Hepatocellular Carcinoma Microenvironment
Key Points
MAIN FINDING: Immunosuppressive macrophage subtypes are identified in the HBV-positive hepatocellular carcinoma microenvironment.
KEY EVIDENCE: Levels of phosphorylated HSP27, STAT1, and TRIM28 were examined in tumor-associated macrophages (TAMs).
APPROACH: The study employed single-cell analysis to investigate posttranslational modifications in macrophages.
SIGNIFICANCE: Understanding these macrophage subtypes may inform new treatment strategies targeting immunosuppression in liver cancer.
Abstract
The expression levels of phosphorylated HSP27 (p-HSP27, S82), phosphorylated STAT1 (p-STAT1, S727), and phosphorylated TRIM28 (p-TRIM28, S473) in TAMs