Table S9 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• RGN6024 is identified as a small-molecule tubulin destabilizer effective against glioblastoma.
• The drug's cellular permeability allows it to penetrate the brain barrier, enhancing its effectiveness.
• Research demonstrates that RGN6024 can disrupt microtubules, crucial for cancer cell structure and function.
• The findings suggest RGN6024 may offer a new avenue for glioblastoma treatment, addressing a high-need area in oncology.