Table S10 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• MAIN FINDING: RGN6024 is identified as a brain-penetrant tubulin destabilizer suitable for glioblastoma therapy.
• KEY EVIDENCE: Administration of RGN6024 at 30 mg/kg resulted in measurable plasma and brain levels in ICR mice.
• APPROACH: The study utilized oral dosing in ICR mice to assess the pharmacokinetics of RGN6024.
• SIGNIFICANCE: These findings support the development of RGN6024 as a promising treatment option for glioblastoma.