Figure S1 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

• Inhibition of mTOR led to initiation of ferritinophagy and ferroptosis in HNSCC.
• Genome-wide screening indicated that disrupting the autophagy pathway is key to mTORi resistance.
• This analysis leverages comprehensive data from CRISPR screenings to identify cellular responses and pathways.
• These findings may inform future therapeutic interventions targeting mTOR and autophagy in head and neck cancer.

Abstract