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August 15, 2025Open Access

Figure S1 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Keiichi Koshizuka Xingyu Wu Kuniaki Sato Pham Thuy Tien Vo Gosia M. Murawska Tomohiko Ishikawa Zhiyong Wang Alfredo Molinolo Edward A. Dennis Cherie‐Ann O. Nathan Prashant Mali J. Silvio Gutkind

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Key Points

Inhibition of mTOR led to initiation of ferritinophagy and ferroptosis in HNSCC.
Genome-wide screening indicated that disrupting the autophagy pathway is key to mTORi resistance.
This analysis leverages comprehensive data from CRISPR screenings to identify cellular responses and pathways.
These findings may inform future therapeutic interventions targeting mTOR and autophagy in head and neck cancer.

Implication

Genome-wide CRISPR screening reveals mTOR inhibition leads to ferritinophagy and ferroptosis in HNSCC, suggesting potential treatment avenues.

Abstract

Genome-wide CRISPR screening identified inhibition of the Autophagy pathway as the mechanism of mTORi resistance in HNSCC. (Related to Figure 1)

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Cite This Study

Koshizuka et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd109 https://doi.org/10.1158/0008-5472.29919056

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S2 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
2Figure S6 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
3Figure S4 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
4Figure S5 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
5Figure S7 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025

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Figure S3 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
Figure S14 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
Figure S9 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025