Figure S9 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Keiichi Koshizuka; Xingyu Wu; Kuniaki Sato; Pham Thuy Tien Vo; Gosia M. Murawska; Tomohiko Ishikawa; Zhiyong Wang; Alfredo A. Molinolo; Edward A. Dennis; Cherie‐Ann O. Nathan; Prashant Mali; J. Silvio Gutkind

doi:10.1158/0008-5472.29919002

August 15, 2025Open Access

Figure S9 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

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Key Points

mTOR inhibition initiates ferritinophagy and ferroptosis, providing a possible cancer treatment pathway.
Key evidence shows that mTORC1 is involved in ferroptosis and ferritinophagy.
Analysis utilizes genome-wide CRISPR screening to link mTOR pathway to cancer progression.
Findings highlight a novel mechanism in head and neck cancer, with implications for targeted therapies.

Implication

Genome-wide CRISPR screening reveals mTOR inhibition induces ferritinophagy and ferroptosis in head and neck cancer, suggesting potential therapeutic targets.

Abstract

mTORC1 is involved in the induction of ferroptosis and ferritinophagy. (Related to Figure 3)

Discussion

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Cite This Study

Koshizuka et al. (2025) studied this question.

synapsesocial.com/papers/68af6203ad7bf08b1eae2de5 https://doi.org/10.1158/0008-5472.29919002

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Figure S9 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S9 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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