Figure S5 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Keiichi Koshizuka; Xingyu Wu; Kuniaki Sato; Pham Thuy Tien Vo; Gosia M. Murawska; Tomohiko Ishikawa; Zhiyong Wang; Alfredo A. Molinolo; Edward A. Dennis; Cherie‐Ann O. Nathan; Prashant Mali; J. Silvio Gutkind

doi:10.1158/0008-5472.29919017

August 15, 2025Open Access

Figure S5 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

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Key Points

mTOR inhibition initiates ferritinophagy in HNSCC cells and patient samples, facilitating cell death.
Experiments demonstrate that inhibiting mTOR leads to observable effects on ferritinophagy and ferroptosis.
Analysis employs genome-wide CRISPR screening to uncover the mechanisms involved in cancer cell death under mTOR inhibition.
Findings highlight the potential of targeting mTOR for therapeutic strategies in managing head and neck cancer.

Implication

Genome-wide CRISPR screening reveals mTOR inhibition initiates ferritinophagy and ferroptosis in HNSCC cells, suggesting potential cancer treatment pathways.

Abstract

mTORi induces ferritinophagy in HNSCC cells and patient samples. (Related to Figure 3)

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Cite This Study

Koshizuka et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd1ed https://doi.org/10.1158/0008-5472.29919017

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Figure S5 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S5 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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