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August 15, 2025Open Access

Figure S14 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Keiichi Koshizuka Xingyu Wu Kuniaki Sato Pham Thuy Tien Vo Gosia M. Murawska Tomohiko Ishikawa Zhiyong Wang Alfredo Molinolo Edward A. Dennis Cherie‐Ann O. Nathan Prashant Mali J. Silvio Gutkind

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Key Points

mTOR inhibition initiates both ferritinophagy and ferroptosis in head and neck cancer, enhancing treatment options.
The study shows that combining mTOR inhibitors with auranofin leads to increased efficacy, indicating synergistic effects.
Using genome-wide CRISPR screening, the analysis identifies critical pathways involved in cancer progression and response to treatment.
These findings highlight the importance of targeting mTOR pathways, which may improve treatment strategies for HNSCC patients.

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Implication

Genome-wide analysis reveals mTOR inhibition triggers ferritinophagy and ferroptosis in HNSCC, suggesting potential therapeutic strategies.

Abstract

mTORi and auranofin show synergy in HNSCC. (Related to Figure 6)

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Cite This Study

Koshizuka et al. (2025) studied this question.

synapsesocial.com/papers/68af6203ad7bf08b1eae2de7 https://doi.org/10.1158/0008-5472.29919041

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S6 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
2Figure S15 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
3Figure S7 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
4Figure S5 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
5Figure S16 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025