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August 15, 2025Open Access

Figure S6 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Keiichi Koshizuka Xingyu Wu Kuniaki Sato Pham Thuy Tien Vo Gosia M. Murawska Tomohiko Ishikawa Zhiyong Wang Alfredo Molinolo Edward A. Dennis Cherie‐Ann O. Nathan Prashant Mali J. Silvio Gutkind

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Key Points

mTOR inhibition triggers ferritinophagy and ferroptosis in head and neck cancer cells, fostering cell death.
Evidence shows mTOR inhibition significantly impacts ferritinophagy and ferroptosis pathways in cancerous cells.
Analysis involved genome-wide CRISPR screening to assess the role of mTOR and its effects on ferritinophagy.
These findings highlight mTOR's potential as a target for therapies aimed at treating head and neck cancer.

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Implication

CRISPR screening shows mTOR inhibition increases ferroptosis in head and neck cancer cells, indicating new therapeutic avenues.

Abstract

mTORi induces ferritinophagy in HNSCC cells. (Related to Figure 3)

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Cite This Study

Koshizuka et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd12f https://doi.org/10.1158/0008-5472.29919011

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S7 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
2Figure S4 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
3Figure S5 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
4Figure S2 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
5Figure S8 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025