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August 15, 2025Open Access

Figure S4 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Keiichi Koshizuka Xingyu Wu Kuniaki Sato Pham Thuy Tien Vo Gosia M. Murawska Tomohiko Ishikawa Zhiyong Wang Alfredo Molinolo Edward A. Dennis Cherie‐Ann O. Nathan Prashant Mali J. Silvio Gutkind

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Key Points

mTOR inhibition triggers ferroptosis, potentially aiding cancer treatment.
Key evidence shows mTOR inhibition leads to significant ferroptosis in head and neck cancer cells.
Observational analysis demonstrates the link between mTOR inhibition and ferritinophagy activation.
These findings may enable new therapeutic strategies for head and neck cancer treatment.

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Implication

Genome-wide CRISPR screening reveals mTOR inhibition induces ferroptosis in HNSCC, suggesting a novel treatment avenue.

Abstract

mTORi induces ferroptosis in HNSCC cells. (Related to Figure 2)

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Cite This Study

Koshizuka et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd19d https://doi.org/10.1158/0008-5472.29919020

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S6 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
2Figure S7 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
3Figure S2 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
4Figure S5 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
5Figure S3 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025