August 15, 2025Open Access

Figure S3 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

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mTOR inhibition induces ferroptosis in head and neck cancer, enhancing tumor cell death.
Targeted drug screening revealed significant effects on ferroptosis through mTOR inhibition.
Observational analysis indicates mTOR inhibitors may serve as effective treatments against head and neck cancer.
Findings suggest the need for further investigation of mTOR inhibition in clinical settings.

Implication

Targeted drug mini-screen shows mTOR inhibition induces ferroptosis in head and neck cancer, suggesting therapeutic potential.

A targeted drug mini-screen indicates that mTORi induces ferroptosis to HNSCC. (Related to Figure 1)

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Koshizuka et al. (2025) studied this question.

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Targeted drug mini-screen shows mTOR inhibition induces ferroptosis in head and neck cancer, suggesting therapeutic potential.

A targeted drug mini-screen indicates that mTORi induces ferroptosis to HNSCC. (Related to Figure 1)