Figure S8 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Keiichi Koshizuka; Xingyu Wu; Kuniaki Sato; Pham Thuy Tien Vo; Gosia M. Murawska; Tomohiko Ishikawa; Zhiyong Wang; Alfredo A. Molinolo; Edward A. Dennis; Cherie‐Ann O. Nathan; Prashant Mali; J. Silvio Gutkind

doi:10.1158/0008-5472.29919005

August 15, 2025

Figure S8 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

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Key Points

Inhibition of mTORC1 triggers ferroptosis in head and neck cancer cells, promoting cell death.
Key findings include the connection between mTORC1 and ferritinophagy as contributors to ferroptosis.
This observational analysis highlights how mTORC1 influences cellular processes in cancer biology.
These results may enable future therapies targeting mTORC1 in treating head and neck cancer.

Implication

Genome-wide CRISPR screening reveals mTORC1's role in initiating ferroptosis and ferritinophagy in head and neck cancer, indicating potential therapeutic avenues.

Abstract

mTORC1 is involved in the induction of ferroptosis and ferritinophagy. (Related to Figure 3)

Discussion

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Cite This Study

Koshizuka et al. (2025) studied this question.

synapsesocial.com/papers/68af5bafad7bf08b1eadf34a https://doi.org/10.1158/0008-5472.29919005

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Figure S8 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S8 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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