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August 15, 2025Open Access

Figure S16 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Keiichi Koshizuka Xingyu Wu Kuniaki Sato Pham Thuy Tien Vo Gosia M. Murawska Tomohiko Ishikawa Zhiyong Wang Alfredo Molinolo Edward A. Dennis Cherie‐Ann O. Nathan Prashant Mali J. Silvio Gutkind

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Key Points

mTOR inhibition triggers ferroptosis, showing a possible new pathway in cancer treatment.
Ferrostatin-1 lessened mTOR inhibitor effects, evidencing its role in cell death processes.
Genome-wide CRISPR screening was employed to identify key pathways and mechanisms in head and neck cancer.
These findings suggest that targeting ferritinophagy may enhance therapeutic approaches and improve outcomes.

Implication

Genome-wide CRISPR screening shows mTOR inhibition causes ferroptosis in head and neck cancer, indicating potential therapeutic targets.

Abstract

Ferrostatin-1 attenuated the effects of mTORi and auranofin in vitro. (Related to Figure 6)

Discussion

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Cite This Study

Koshizuka et al. (2025) studied this question.

synapsesocial.com/papers/68af5bb6ad7bf08b1eadf3a3 https://doi.org/10.1158/0008-5472.29919035

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S18 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
2Figure S17 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
3Figure S15 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
4Figure S14 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
5Figure S8 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025