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August 15, 2025Open Access

Figure S18 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Keiichi Koshizuka Xingyu Wu Kuniaki Sato Pham Thuy Tien Vo Gosia M. Murawska Tomohiko Ishikawa Zhiyong Wang Alfredo Molinolo Edward A. Dennis Cherie‐Ann O. Nathan Prashant Mali J. Silvio Gutkind

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Key Points

Inhibition of mTOR initiates ferritinophagy and ferroptosis in head and neck cancer cells, potentially aiding treatment strategies.
Ferrostatin-1 reduces the impact of mTOR inhibitors and auranofin by diminishing ferroptosis in vivo, hinting at therapeutic potential.
The research utilized genome-wide CRISPR screening to uncover these cellular mechanisms behind cancer progression and treatment.
Understanding how mTOR inhibition influences ferroptosis highlights new directions in cancer care and requires further exploration.

Implication

Genome-wide CRISPR screening reveals mTOR inhibition triggers ferritinophagy and ferroptosis, suggesting potential cancer therapies.

Abstract

Ferrostatin-1 attenuated the effects of mTORi and auranofin by suppressing ferroptosis in vivo. (Related to Figure 7)

Discussion

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Cite This Study

Koshizuka et al. (2025) studied this question.

synapsesocial.com/papers/68af5d63ad7bf08b1eae07ba https://doi.org/10.1158/0008-5472.29919029

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S16 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
2Figure S17 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
3Figure S15 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
4Figure S8 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025
5Figure S9 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer2025