Supplementary Fig. S4 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy

Key Points

• Sensitivity analysis shows significant predictors impacting tumor volume before treatment, highlighting critical factors.
• Contributors to tumor volume were identified with a p-value <0.05 through ANOVA, informing treatment strategies.
• Analysis included global sensitivity methods applied to tumor response models based on gut microbiome interactions.
• Identifying significant predictors supports potential enhancements in immunotherapy, though population-specific validation is essential.