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August 15, 2025Open Access

Supplementary Fig. S4 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy

Andreas G. Hadjigeorgiou Constantinos Harkos Aditya K. Mishra Golnaz Morad Sarah B. Johnson Nadim J. Ajami Jennifer A. Wargo Lance L. Munn Triantafyllos Stylianopoulos Rakesh K. Jain

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Key Points

Sensitivity analysis shows significant predictors impacting tumor volume before treatment, highlighting critical factors.
Contributors to tumor volume were identified with a p-value <0.05 through ANOVA, informing treatment strategies.
Analysis included global sensitivity methods applied to tumor response models based on gut microbiome interactions.
Identifying significant predictors supports potential enhancements in immunotherapy, though population-specific validation is essential.

Implication

Sensitivity analysis reveals significant predictors affecting tumor volume in cancer therapy and gut microbiome interactions.

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Cite This Study

Hadjigeorgiou et al. (2025) studied this question.

synapsesocial.com/papers/68af50a1ad7bf08b1ead8a03 https://doi.org/10.1158/0008-5472.29918657

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Fig. S5 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025
2Supplementary Fig. S2 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025
3Supplementary Fig. S6 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025
4Supplementary Information from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025
5Supplementary Data from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025

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Supplementary Fig. S1 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025
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Supplementary Fig. S3 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025