Supplementary Fig. S1 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy

Andreas G. Hadjigeorgiou; Constantinos Harkos; Aditya K. Mishra; Golnaz Morad; Sarah B. Johnson; Nadim J. Ajami; Jennifer A. Wargo; Lance L. Munn; Triantafyllos Stylianopoulos; Rakesh K. Jain

doi:10.1158/0008-5472.29918669

August 15, 2025Open Access

Supplementary Fig. S1 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy

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Key Points

The mathematical model demonstrates how the gut microbiome can influence immune responses in cancer treatment, highlighting its potential importance.
Key immune components, such as PD-1 and PD-L1, are integrated into the model, indicating their role in tumor interactions.
This research employs a mathematical approach to assess immune system dynamics, focusing on factors like cytokines and immunosuppressive cells.
The findings suggest that understanding the gut microbiome could enhance cancer immunotherapy strategies and effectiveness.

Implication

Mathematical model reveals cytokine effects and immune modulation in cancer, suggesting new immunotherapy strategies.

Abstract

Schematic of the mathematical model of tumor-immune system interactions, highlighting key immune components, their activation and cytolytic functions, and modulation by PD-1/PD-L1 signaling. The model also incorporates cytokine effects and the influence of immunosuppressive cells like M2 macrophages and Tregs.

Discussion

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Cite This Study

Hadjigeorgiou et al. (2025) studied this question.

synapsesocial.com/papers/68af50a1ad7bf08b1ead894d https://doi.org/10.1158/0008-5472.29918669

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Supplementary Fig. S1 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Fig. S1 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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