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August 15, 2025

Supplementary Fig. S3 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy

Andreas G. Hadjigeorgiou Constantinos Harkos Aditya K. Mishra Golnaz Morad Sarah B. Johnson Nadim J. Ajami Jennifer A. Wargo Lance L. Munn Triantafyllos Stylianopoulos Rakesh K. Jain

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Key Points

The findings suggest that the gut microbiome could influence cancer immunotherapy outcomes, potentially improving patient responses.
Analysis identified key principal components reflecting microbiome diversity among murine samples, helping to elucidate the relationship with cancer.
Mathematical modeling was utilized to assess microbiome interactions with cancer therapies, providing insights on treatment strategies.
Understanding these interactions highlights the importance of microbiome modulation in enhancing immunotherapy efficacy.

Implication

Analysis of gut microbiome associations with cancer outcomes in a murine dataset, indicating potential treatment implications.

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Cite This Study

Hadjigeorgiou et al. (2025) studied this question.

synapsesocial.com/papers/68af5bafad7bf08b1eadf361 https://doi.org/10.1158/0008-5472.29918660

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Fig. S6 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025
2Supplementary Fig. S4 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025
3Supplementary Fig. S2 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025
4Supplementary Information from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025
5Supplementary Fig. S5 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025

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Supplementary Data from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy2025
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