Figure S8 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

• Inhibition of mTORC1 triggers ferroptosis in head and neck cancer cells, promoting cell death.
• Key findings include the connection between mTORC1 and ferritinophagy as contributors to ferroptosis.
• This observational analysis highlights how mTORC1 influences cellular processes in cancer biology.
• These results may enable future therapies targeting mTORC1 in treating head and neck cancer.

Abstract