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August 18, 2025

Vitamine D in Chronic Obstructive Pulmonary Disease Patient and Its Relation to Severity and Acute Exacerbation

Key Points

Vitamin D deficiency may worsen functional impairment in COPD patients, impacting respiratory health significantly.
A positive correlation observed between vitamin D levels and pulmonary function metrics like FVC and FEV1.
This case-control study involved 50 COPD patients aged 40-80 and 50 age-matched healthy controls for comparison.
Monitoring vitamin D levels could play a critical role in managing COPD and preventing acute exacerbations.

Abstract

Background: Decreased 25-OH-vitamin D (Vit D) levels may develop lung damage. Functional impairment in chronic obstructive pulmonary disease (COPD) may be correlated with a decline in health as indicated by 25-OH- Vit D levels. Objective: We aimed to evaluate the correlation between COPD severity, acute exacerbation, and the Vit D levels in COPD cases. Methodology: This hospital-based case-control study was performed on 50 COPD cases ranged in age between 40 and 80 years old, both genders, and 50 healthy individuals matched in age and sex. All cases were subjected to physical investigations, laboratory investigations, and pulmonary function assessments Forced vital capacity (FVC), Forced expiratory flow (FEF) 25%, Forced expiratory volume in one second (FEV1), PEF, and FEF 50%, and FEF 75%. Results: Between Vit D and smoking index, FVC, FEV1, FEF 25–75 and Six-minute walk a statically significant positive correlation was indicated test (P<0.05), while there were statically significant Negative correlation Between Vit D and, HR, CAT score and MMRC (P=0.043, 0.000, 0.000, respectively) in group A.Conclusions: Vit D deficiency may contribute to the functional impairment observed in COPD and highlight the potential therapeutic value of monitoring and correcting Vit D levels in managing COPD.

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