Figure S9 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• B7-H3 CAR T-cells demonstrate effectiveness against ependymomas, yet their impact is limited by tumor size and immune response.
• Type 2 polarization of B7-H3 CAR T-cells occurs after repetitive stimulation with ependymoma cells, suggesting adaptive responses.
• Analysis of CAR T-cells targeting B7-H3 shows notable results, but challenges from tumor size and immune interactions remain.
• Implications from the study highlight the need for further research on enhancing CAR T-cell efficacy against solid tumors.