Figure S3 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• B7-H3 CAR T cells effectively target ependymomas, but their efficacy diminishes with larger tumor size.
• Regulation of B7-H3 transcriptional activity by ZFTA-RELA oncogene demonstrates the complexity of immune responses.
• Analysis of relationship between tumor size and immune response using B7-H3 CAR T cells reveals significant challenges.
• Findings indicate potential for targeted therapy, but limits imposed by immune response and tumor size need addressing.