Figure S18 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• Antitumor efficacy of B7-H3 CAR T cells decreases as tumor size increases, and immune response plays a crucial role.
• The study demonstrates the relationship between tumor volume and CAR T cell efficacy, emphasizing immune response limits.
• The findings reveal that CAR T cells are a promising approach for treating Ependymomas but face critical limitations.
• Understanding these limitations is vital for improving CAR T cell therapy outcomes in patients with Ependymomas.