Figure S16 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• B7-H3 CAR T-cells demonstrated high efficacy against xenograft tumors, but their effectiveness is limited by tumor size.
• Durability of B7-H3 CAR T-cells is less robust in the presence of an immune response, affecting treatment outcomes.
• Xenograft models in vivo highlighted the complexity of using B7-H3 CAR T-cell therapy against ependymomas.
• Size and immune interference present significant challenges in optimizing B7-H3 CAR T-cell treatments for ependymomas.