Supplementary Figure 7 from Microbiota Shape Metabolic and Immune Determinants of CAR-T Therapy and Correlate with Outcomes in Myeloma

Key Points

• Higher serum succinate levels correlate with alterations in CD4+ and CD8+ T-cell memory compartments.
• Evidence shows that metabolic determinants significantly influence CAR T-cell therapy outcomes in myeloma.
• Analysis of apheresis samples provides insights into immune interactions influencing therapeutic efficacy.
• These findings may highlight potential targets for enhancing CAR T-cell therapy effectiveness.