What type of study is this?

This is a Cross-Sectional study.

September 10, 2025

Clinicopathological Characteristics of Breast Cancer Patients: A Cross-Sectional Analysis From Zia Uddin Hospital, Karachi.

Key Points

The majority of breast cancer patients presented with Stage III disease, indicating an aggressive profile and late diagnosis.
Hormonal evaluations revealed significant negatives in estrogen and progesterone, indicating a need for targeted therapies.
Lymph node involvement was noted in 92.5% of cases, emphasizing the importance of early detection for better treatment outcomes.
Poorly differentiated tumors (Grade III) were predominant, highlighting the urgency for personalized treatment strategies.

Abstract

Background: Breast cancer is the leading malignancy among women in Pakistan, with late-stage diagnoses and limited systematic data worsening outcomes. Objective:To analyze clinicopathological features of breast cancer at Zia Uddin University Hospital and highlight needs for early detection and targeted therapy. Methods: A cross-sectional study of 80 female patients (ages 20–70 years) with invasive ductal carcinoma (IDC). Tumor size, stage, grade, and hormonal profiles (ER, PR, HER2/neu) were assessed. Results: The majority of patients (61%) were aged 40–60 years, with 63.8% presenting at Stage III, and 71.3% having tumors ≥5 cm. Lymph node involvement was noted in 92.5% of cases, highlighting an aggressive disease profile. All cases were invasive ductal carcinoma (IDC), with poorly differentiated tumors (Grade III) accounting for 61.3%. Hormonal analysis revealed ER negativity in 47.5%, PR negativity in 62.5%, and HER2/neu positivity in 31.3%, indicating a significant subset eligible for targeted therapies. Conclusion: Findings reveal disease profile requiring early detection, personalized treatments, and HER2/neu-targeted therapies. Systematic cancer registries and public awareness are essential for better outcomes.

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