Cross-sectional analysis identifies aggressive breast cancer profiles in 80 women, suggesting early detection and targeted therapies are crucial.
Background: Breast cancer is the leading malignancy among women in Pakistan, with late-stage diagnoses and limited systematic data worsening outcomes. Objective:To analyze clinicopathological features of breast cancer at Zia Uddin University Hospital and highlight needs for early detection and targeted therapy. Methods: A cross-sectional study of 80 female patients (ages 20–70 years) with invasive ductal carcinoma (IDC). Tumor size, stage, grade, and hormonal profiles (ER, PR, HER2/neu) were assessed. Results: The majority of patients (61%) were aged 40–60 years, with 63.8% presenting at Stage III, and 71.3% having tumors ≥5 cm. Lymph node involvement was noted in 92.5% of cases, highlighting an aggressive disease profile. All cases were invasive ductal carcinoma (IDC), with poorly differentiated tumors (Grade III) accounting for 61.3%. Hormonal analysis revealed ER negativity in 47.5%, PR negativity in 62.5%, and HER2/neu positivity in 31.3%, indicating a significant subset eligible for targeted therapies. Conclusion: Findings reveal disease profile requiring early detection, personalized treatments, and HER2/neu-targeted therapies. Systematic cancer registries and public awareness are essential for better outcomes.
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Zafar et al. (2024) studied this question.
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