Abstract Spondias purpurea L. is widely used in folk medicine to treat various pathological conditions. One of its promising activities is antimicrobial. The present work aimed to characterize the composition and evaluate the antifungal and antibacterial effects of aqueous (AESP) and ethanolic (EESP) extracts of leaves. The technique of ultra‐performance liquid chromatography coupled to a quadruple time‐of‐flight system (UPLC‐QTOF) was used for phytochemical qualification. For the antifungal tests, two strains of Candida albicans were used, and for the antibacterial tests, strains of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were used. Quercetin, Kaempferol, Quinic Acid, gallo (epi)catechin dimer, dehydroascorbic acid, and quercetin derivative were detected in AESP, and quinic acid, iriflofenone 3‐C‐β D glycopyranoside, chlorogenic acid, and stearidonic acid in EESP. It was found that AESP potentiated the action of amikacin against bacteria, and an antifungal effect of both extracts was observed at a concentration of 8,192 µg/mL for the CA URM 4127 strain. The two evaluated extracts significantly potentiated the effect of fluconazole against CA INCQS 40006. The research showed that the extracts tested alone do not present significant antibacterial or antifungal activities at low concentrations against the tested strains. However, they demonstrated potentiating effect of already standardized drugs.
Silva et al. (Mon,) studied this question.