What type of study is this?

This is a Quantitative Study study.

September 16, 2025

Rp - Hplc Method Development And Validation For The Simultaneous Determination Of Cabotegravir And Rilpivirine In Pharmaceutical Dosage Form.

Key Points

The RP-HPLC method successfully estimated cabotegravir and rilpivirine in under three minutes, improving pharmaceutical analysis efficiency.
Key validation metrics showed excellent reliability and accuracy, with %RSD and %Recovery meeting ICH guidelines for analytical methods.
Chromatographic separation was achieved using Kromasil C18 column with a specific mobile phase composition, optimizing the method's effectiveness.
The method demonstrated retention times of 2.225 min for cabotegravir and 2.609 min for rilpivirine, indicating effective separation between compounds.

Abstract

A straightforward and precise RP-HPLC method was developed for the simultaneous estimation of Rilpivirine and Cabotegravir in pharmaceutical dosage form. The chromatographic separation was achieved using a Kromasil C18 column with 0.1% ortho-phosphoric acid:acetonitrile (40:60 v/v) as the mobile phase 14. Wavelength was optimized at 260 nm 17. Retention times were 2.225 min for Cabotegravir and 2.609 min for Rilpivirine. Validation parameters such as %RSD, %Recovery, LOD/LOQ, and linear regression equations demonstrated reliability, reproducibility, and accuracy per ICH guidelines

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