RP-HPLC method estimates cabotegravir and rilpivirine in pharmaceutical formulations, highlighting reliable separation.
A straightforward and precise RP-HPLC method was developed for the simultaneous estimation of Rilpivirine and Cabotegravir in pharmaceutical dosage form. The chromatographic separation was achieved using a Kromasil C18 column with 0.1% ortho-phosphoric acid:acetonitrile (40:60 v/v) as the mobile phase [14]. Wavelength was optimized at 260 nm [17]. Retention times were 2.225 min for Cabotegravir and 2.609 min for Rilpivirine. Validation parameters such as %RSD, %Recovery, LOD/LOQ, and linear regression equations demonstrated reliability, reproducibility, and accuracy per ICH guidelines
No takes yet. Share an insight, caveat, or question.
Rathod et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: