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This is a Experimental Study study.

September 17, 2025

Metabolic Imaging of Hyperpolarized 1-13CPyruvate in a Ferret Model of Traumatic Brain Injury

Key Points

Reduced bicarbonate levels indicate impaired energy metabolism following traumatic brain injury.
A notable decrease in the bicarbonate to pyruvate ratio was observed 8-10 days after TBI.
Metabolic imaging utilized hyperpolarized [1-13C]pyruvate to assess brain energy metabolism changes.
Findings may enhance the understanding of TBI and improve approaches in drug development.

Abstract

Motivation: Traumatic brain injury (TBI) represents a huge personal and economic burden. However, treatments and screening tools successfully developed in preclinical TBI models have failed to translate to the clinic. Goal(s): To noninvasively measure brain energy metabolism after injury in a ferret model of TBI as ferrets possess primate-like gyrencephalic brains that may better replicate the human response to neurologic injury. Approach: Metabolic imaging of hyperpolarized (HP) 1-13Cpyruvate and its conversion to lactate (Lac) and bicarbonate (Bic) was used in ferrets before and after injury. Results: Reduced Bic/Pyr, reflecting reduced PDH activity, was detected 8-10 days post-injury whereas no difference in Lac/Pyr was observed. Impact: Metabolic imaging of HP 1-13Cpyruvate for the noninvasive investigation of perturbations in brain energy metabolism in a highly translatable animal model of TBI may contribute to both improved understanding of injury mechanisms and more effective drug development.

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