Objective As the survival of cancer patients improves, the incidence of bone metastases increases. Acetabular metastases often cause severe pain, limit hip mobility, and impair quality of life. Percutaneous cement augmentation (PCA) provides short-term pain relief and improves mechanical stability, but its anti-tumor effect is limited. 125 I seed brachytherapy offers precise local tumor control but cannot enhance bone strength. We proposed a novel strategy combining 125 I seeds with cement augmentation to achieve better tumor killing and bone stabilization. Methods We retrospectively analyzed 64 patients (determined by power analysis assuming α=0.05, β=0.2, and expected difference in VAS scores of 1.5) with acetabular metastases who underwent either PCA alone (group A, n=34) or 125 I seed brachytherapy plus PCA (group B, n=30) between December 2008 and December 2022. Pain intensity (VAS), functional status (ECOG), and complications were evaluated as primary endpoints before and up to 6 months after treatment. Survival analysis was performed using Kaplan-Meier method with log-rank test. Results The two groups had similar baseline characteristics. Group B showed significantly lower mean VAS scores (mean difference: 2.1; 95% CI: 1.6-2.6; p 0.001) and ECOG scores (mean difference: 1.51; 95% CI: 1.1-1.9; p 0.001) at 6 months post-treatment compared to group A. Complication rates were comparable between groups (5.9% vs 3.0%, p = 0.62), with no significant difference in median survival (16.8 vs 16.7 months, p = 0.85). Conclusion Combined ¹² 5 I seed brachytherapy and PCA (¹² 5 I-PCA) provides superior long-term pain control and functional outcomes compared to PCA alone for acetabular metastases. This is attributed to the synergistic effect of PMMA-mediated mechanical stabilization and continuous low-dose radiation-induced tumor suppression, effectively addressing the transient cytoreduction limitation of standalone PCA. Integration of TPS(Treatment Planning System)-guided brachytherapy dosing with precise CT-guided cementoplasty represents an effective and safe palliative strategy for these complex lesions.
Sun et al. (Fri,) studied this question.