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September 18, 2025

Pharmacological prevention of recurrent urinary tract infections

Key Points

Non-antibiotic treatments show comparable efficacy to low-dose antibiotics for recurrent UTIs, indicating promising alternatives.
Evidence highlights cranberry products and methenamine hippurate as effective options for preventing recurrent UTIs.
Prioritizing non-antibiotic alternatives can help reduce antibiotic use and combat the development of antibiotic resistance.
High-quality studies are essential to further validate the effectiveness and implications of these non-antibiotic treatments.

Abstract

For severe recurrent urinary tract infections (rUTIs), pharmacological prevention may be necessary. This review finds that existing data indicate that non-antibiotic treatments, such as cranberry products, methenamine hippurate, and vaginal estrogen for postmenopausal women, demonstrate efficacy comparable to low-dose antibiotics. These alternatives should be prioritised to reduce antibiotic use, development of resistance, and side effects. High-quality studies are needed to validate current evidence.

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Authors

Astrid Johannesson Hjelholt

Aarhus University Hospital

Thomas Johannesson Hjelholt

Institute of Clinical Research

Samuel Azuz

Aalborg University Hospital

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Pharmacological prevention of recurrent urinary tract infections

Key Points

Abstract

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Discussion

Authors

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References and Citations

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