What type of study is this?

This is a In Vitro Study study.

September 20, 2025

Two new lignanamides from the fruits of Tribulus terrestris with NO production inhibitory activity

Key Points

Lignanamides from Tribulus terrestris exhibit significant NO production inhibitory activity in a cellular model.
Compounds 1 and 2 are newly described lignanamides showing IC50 values between 5.8 to 26.5 µM.
The study employed advanced methods like HR‐ESI‐MS and NMR to confirm the structures of the lignanamides.
These findings may advance understanding of anti-inflammatory properties and therapeutic potentials of lignanamides.

Abstract

Abstract Lignanamides are lignans containing amide functional groups, which show significantly anti‐inflammatory. From the Tribulus terrestris fruits, six lignanamides ( 1 ‐ 6 ) and four other nitrogen compounds ( 7 ‐ 10 ) were isolated. Of which, compounds 1 and 2 were previously undescribed. Their structures were elucidated by HR‐ESI‐MS, 1D, 2D‐NMR, and ECD spectra in comparison with the reported data. Lignanamides 1 – 6 significantly exhibited NO production inhibitory activity in LPS activated RAW 264.7 cells with IC 50 values ranging from 5.8 to 26.5 µM.

Two new lignanamides from the fruits of Tribulus terrestris with NO production inhibitory activity

Key Points

Abstract

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