Isolation of new lignanamides from Tribulus terrestris fruits demonstrates anti-inflammatory effects, suggesting potential therapeutic use.
Lignanamides are lignans containing amide functional groups, which show significantly anti‐inflammatory. From the Tribulus terrestris fruits, six lignanamides ( 1 ‐ 6 ) and four other nitrogen compounds ( 7 ‐ 10 ) were isolated. Of which, compounds 1 and 2 were previously undescribed. Their structures were elucidated by HR‐ESI‐MS, 1D, 2D‐NMR, and ECD spectra in comparison with the reported data. Lignanamides 1 – 6 significantly exhibited NO production inhibitory activity in LPS activated RAW 264.7 cells with IC 50 values ranging from 5.8 to 26.5 µM.
No takes yet. Share an insight, caveat, or question.
Quốc et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: