Abstract In a previous paper we developed Quantitative Ion Character-Activity Relationships (QICARs) to relate the intrinsic properties of a metal to its acute toxicity towards freshwater aquatic organisms. These predictive tools were developed for a set of data-rich training elements and then applied to a representative selection of Technology-Critical Elements (TCEs). The toxicity of the TCEs was reasonably well predicted, with most values located within the 95% prediction intervals. In the present work we have extended this approach to use the calculated metal speciation. Linear Free Energy Relationships were used to estimate some of the needed thermodynamic constants. Using this information, we expressed the concentration resulting in a 50% effect level (EC50) values as free metal activities and performed the regression analyses. For the training metals, the determination coefficients slightly increased compared to those obtained using the total dissolved metal. As before, the log transformed composite value of the covalent index (χm 2r) was the best predictor of their acute toxicity towards algae and daphnids (χm = metal’s electronegativity; r = ionic radius). However, for the TCEs the regressions were much poorer, particularly when the predicted free metal ion concentrations were very low (e.g., less than 10−18 M). We suggest that this result reflects the distinctive speciation of these metals, where (i) the free metal ion is present only at vanishingly low concentrations (the calculation of which is problematic), and (ii) in all but one case (Au(CN)2 -), the metal’s calculated speciation is dominated by neutral polyhydroxo species (e.g., Au(OH)3 0, Ge(OH)4 0…). In our view, this result does not undermine the use of QICARs. Rather, the use of QICARs has revealed that the free-ion activity could be inadequate for predicting the toxicity of the studied data-poor metals.
Faucheur et al. (Thu,) studied this question.