What type of study is this?

September 24, 2025Open Access

Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation

DKDinushan C. KaluarachchiUniversity of Wisconsin–Madison VCValerie Y. ChockLucile Packard Children's Hospital TBT. BarbaraFlorida State University

Key Points

Death or severe neurodevelopmental impairment occurred in 49% with TCPC, compared to 40% for surgical ligation.
The odds ratio for death or severe neurodevelopmental impairment between TCPC and surgical ligation was 1.12, with a confidence interval of 0.55–2.26.
Infants born at <27 weeks' gestation undergoing the procedures were analyzed in this cohort study.
These findings highlight the need for further evaluation in larger prospective studies as TCPC management evolves.

Abstract

Abstract Background There is a paucity of data on neurodevelopmental outcomes in preterm infants who undergo transcatheter patent ductus arteriosus (PDA) closure (TCPC). Objective To evaluate neurodevelopmental impairment (NDI) or death at 2 years among preterm infants treated with TCPC compared to surgical ligation. Methods Retrospective cohort study of infants born at <27 weeks’ gestation at NICHD NRN sites. Comparisons were made between infants who underwent TCPC and PDA ligation. Results TCPC and surgical ligation were performed on 99 and 279 infants, respectively. Death or severe NDI occurred in 49% of infants with TCPC and 40% with surgical ligation. There was no difference in odds of death or severe NDI between the two groups aOR 1.12 95% CI: 0.55–2.26). Conclusion TCPC had similar odds of death or severe NDI compared to surgical ligation. These findings need to be evaluated in large prospective studies as the management practice around the TCPC evolves. Clinical trial registration ClinicalTrials.gov ID: Generic Database: NCT00063063.

KI fragen

Bookmark

View Full Paper