What type of study is this?

This is a Systematic Review study (also classified as: RCT).

September 28, 2025

Comparative efficacy of nonpharmacological interventions for preventing postoperative delirium in hospitalized older adults: a systematic review and network meta-analysis.

Key Points

Multicomponent nonpharmacological interventions significantly reduced postoperative delirium incidence in older adults, showing great efficacy.
In the analysis, interventions incorporating physical activity and environmental control reduced the odds of postoperative delirium by 52% compared to usual care.
A network meta-analysis of 19 randomized controlled trials assessed the impact of various interventions on delirium in hospitalized older adults.
These findings highlight the necessity for implementing comprehensive approaches that focus on multiple factors to prevent postoperative delirium.

Abstract

Postoperative delirium (POD) is the most common surgical complication. Although numerous studies have demonstrated the effectiveness of multicomponent interventions in preventing delirium among medical patients, the most effective nonpharmacological strategies for reducing the incidence of POD remains unclear. This study aimed to compare the effects of component-based and treatment-based nonpharmacological interventions on POD prevention in hospitalized older adults. A network meta-analysis was conducted using three databases from inception to February 1, 2024. Only randomized controlled trials evaluating nonpharmacological interventions versus usual care or other interventions for POD prevention in surgical older adults were included. A random-effects network meta-analysis assessed the comparative effectiveness of interventions. Nineteen studies involving 4340 hospitalized older adults were included. Component-based analysis showed that multicomponent interventions were the most effective for reducing POD compared to usual care (odds ratio OR = 0.48, 95% confidence interval CI = 0.35-0.66). Treatment-based analysis identified that multicomponent interventions comprising six elements-physical activity, reorientation, clinical adjustment, sensory stimulation, environmental control and relaxation promotion-most effectively reduced POD incidence (OR = 0.11, 95% CI = 0.04-0.33). This network meta-analysis, drawing on both direct and indirect evidence, suggests that multicomponent nonpharmacological interventions are the most effective strategies for reducing POD incidence in hospitalized older adults. Specifically, interventions incorporating physical activity, reorientation, clinical adjustment, sensory stimulation, environmental control and relaxation promotion significantly lowered the risk of POD. These findings support the adoption of comprehensive multicomponent interventions as a first-line approach for POD prevention in surgical older adult populations.

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Cite This Study

Hsiao et al. (Fri,) studied this question.

synapsesocial.com/papers/68d90a0a41e1c178a14f6742 https://doi.org/https://doi.org/10.1093/ageing/afaf264

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