Palladium-Catalyzed Cyanation and Alkynylation of Allylic gem-Difluorides via Hiyama-Type Coupling

Key Points

• The palladium-catalyzed transformation efficiently activates C-F bonds, facilitating a new synthetic pathway.
• Selective C-F bond activation allows for effective coupling with trimethylsilyl cyanide and silylalkynes.
• A tandem sequence involving oxidative addition is central to the mechanism of the Hiyama-type coupling process.
• This approach may enable more efficient synthesis of complex organic molecules by leveraging gem-difluorides.