Enantioselective 2,3-Wittig rearrangement of allyl picolyl ethers with chiral lithium amides | Synapse
October 2, 2025Open Access
Enantioselective 2,3-Wittig rearrangement of allyl picolyl ethers with chiral lithium amides
Key Points
The process achieves up to 95% enantiomeric excess in alcohol production, enhancing synthetic efficiency.
Chiral lithium amides effectively catalyze the [2,3]-Wittig rearrangement of allyl picolyl ethers, leading to valuable products.
This method utilizes 2-(allyloxymethyl)pyridine as the starting material, indicating a novel approach in enantioselective synthesis.
Promising results from this rearrangement reveal potential applications in pharmaceutical and organic synthesis sectors.
Abstract
Highly enantioselective 2,3-Wittig rearrangement of 2-(allyloxymethyl)pyridine using chiral lithium amides to give 1-(2-pyridyl)-3-butenol with up to 95% ee was achieved.