Supplementary Figure S7 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy | Synapse
October 2, 2025Open Access
Supplementary Figure S7 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy
Key Points
Blocking nrf2 translation increases sensitivity of lymphoma cells to ferroptosis and T-cell immunotherapy, enhancing treatment effects.
Key evidence shows treatments with zotatifin and IKE significantly activate cleaved caspase in lymphoma, indicating apoptosis.
The analysis included tumor imaging and immunohistochemistry assessments focusing on cleaved caspases and lipid peroxidation.
These findings highlight the potential for combining nrf2 inhibition with existing lymphoma therapies for improved patient outcomes.
Abstract
Tumor imaging and immunohistochemistry analysis of cleaved caspase 3 and 4-HNE in vivo following zotatifin, IKE, or combination treatment.