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October 1, 2025Open Access

Supplementary Figure S7 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Paola Manara Austin D. Newsam Venu Venkatarame Gowda Saralamma Tyler Andrew Cunningham Drew Lazenby J.J.David Ho Marco Vincenzo Russo Abdessamad Youssfi Alaoui Dhanvantri Chahar Alicia Bilbao Martinez Nikolai Fattakhov Alexandra Marie Carbone Olivia Barbara Farag Alexa Marie Barroso Kyle Hoffman Francesco Maura Daniel Bilbao Jonathan H. Schatz

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Key Points

Blocking nrf2 translation increases sensitivity of lymphoma cells to ferroptosis and T-cell immunotherapy, enhancing treatment effects.
Key evidence shows treatments with zotatifin and IKE significantly activate cleaved caspase in lymphoma, indicating apoptosis.
The analysis included tumor imaging and immunohistochemistry assessments focusing on cleaved caspases and lipid peroxidation.
These findings highlight the potential for combining nrf2 inhibition with existing lymphoma therapies for improved patient outcomes.

Implication

Blocking NRF2 translation improves ferroptosis and CAR T-cell outcomes in lymphoma, suggesting new treatment strategies.

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Cite This Study

Manara et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a2b https://doi.org/10.1158/0008-5472.30255176

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
2Supplementary Figure S8 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
3Supplementary Figure S4 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
4Supplementary Figure S1 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
5Supplementary Figure S6 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025

Supplementary Figure S3 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
Supplementary Figure S5 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
Data from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025