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October 1, 2025

Supplementary Figure S3 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Paola Manara Austin D. Newsam Venu Venkatarame Gowda Saralamma Tyler Andrew Cunningham Drew Lazenby J.J.David Ho Marco Vincenzo Russo Abdessamad Youssfi Alaoui Dhanvantri Chahar Alicia Bilbao Martinez Nikolai Fattakhov Alexandra Marie Carbone Olivia Barbara Farag Alexa Marie Barroso Kyle Hoffman Francesco Maura Daniel Bilbao Jonathan H. Schatz

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Key Points

Induction of ferroptosis was observed in DLBCL cells treated with Zotatifin, indicating a novel therapeutic strategy.
Key metrics involved BODIPY oxidation assessments and GSH/GSSG ratios, showing significant oxidative stress induction.
Assessment using MitoSOX and DHE staining provided clear evidence of mitochondrial and cellular oxidative stress levels.
Findings may highlight the potential for combining NRF2 inhibition with CAR T-cell immunotherapy for better responses.

Implication

Experimental analysis shows ferroptosis increases in DLBCL cells treated with Zotatifin, suggesting enhanced CAR T-cell therapy effectiveness.

Abstract

Zotatifin-induced oxidative stress and ferroptosis in DLBCL cells assessed by BODIPY oxidation, GSH/GSSG ratio, MitoSOX, and DHE staining.

Discussion

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Cite This Study

Manara et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a35 https://doi.org/10.1158/0008-5472.30255188

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S4 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
2Supplementary Figure S6 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
3Supplementary Figure S1 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
4Supplementary Figure S2 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
5Supplementary Figure S7 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025

Supplementary Figure S8 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
Supplementary Figure S5 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
Data from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025