⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

October 1, 2025Open Access

Supplementary Figure S2 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Paola Manara Austin D. Newsam Venu Venkatarame Gowda Saralamma Tyler Andrew Cunningham Drew Lazenby J.J.David Ho Marco Vincenzo Russo Abdessamad Youssfi Alaoui Dhanvantri Chahar Alicia Bilbao Martinez Nikolai Fattakhov Alexandra Marie Carbone Olivia Barbara Farag Alexa Marie Barroso Kyle Hoffman Francesco Maura Daniel Bilbao Jonathan H. Schatz

View Full Paper

Ask AI

Bookmark

Share

Key Points

Targeting NRF2 translation increases lymphoma cell sensitivity to ferroptosis and CAR T-cell immunotherapy.
Key metrics reveal that zotatifin treatment significantly alters the translational landscape and enhances therapeutic response.
Analysis combined immunoblots, pSILAC data, and GSEA enrichment to assess molecular impacts of treatment.
These findings suggest that inhibiting NRF2 translation may improve responses to existing lymphoma therapies.

Implication

Integrated analysis demonstrates NRF2 targeting enhances ferroptosis and CAR T-cell effectiveness in lymphoma cells.

Abstract

Integrated analysis of translation and transcription upon zotatifin treatment, including immunoblots, TMT-pSILAC data, and GSEA enrichment.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Manara et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a77 https://doi.org/10.1158/0008-5472.30255191

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S1 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
2Supplementary Figure S8 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
3Supplementary Figure S6 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
4Supplementary Figure S7 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
5Supplementary Figure S4 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025

Supplementary Figure S5 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
Supplementary Figure S3 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
Data from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025