Supplementary Figure S5 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Q: What type of study is this?

This is a Quantitative Study study.

Paola Manara; Austin D. Newsam; Venu Venkatarame Gowda Saralamma; Tom Cunningham; Drew Lazenby; J.J. David Ho; Marco Vincenzo Russo; Abdessamad Youssfi Alaoui; Dhanvantri Chahar; Alicia Bilbao Martinez; Nikolai Fattakhov; Alexandra Carbone; Olivia Barbara Farag; Alexa Marie Barroso; Kyle S. Hoffman; Francesco Maura; Daniel Bilbao; Jonathan H. Schatz

doi:10.1158/0008-5472.30255182

October 1, 2025Open Access

Supplementary Figure S5 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

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Key Points

Blocking nrf2 translation increases sensitivity to ferroptosis in lymphoma cells, leading to improved treatment outcomes.
The study shows that rocaglates inhibit nrf2 translation via cap-dependent initiation, backed by multiple assays.
Immunoblots and luciferase assays demonstrate the efficacy of rocaglates in reducing nrf2 levels in cancer cells.
By sensitizing lymphoma cells to ferroptosis, this approach may enhance the effectiveness of car t-cell immunotherapy.

Implication

Results demonstrate that blocking nrf2 translation increases ferroptosis sensitivity in lymphoma, highlighting implications for car t-cell immunotherapy.

Abstract

Rocaglates inhibit NRF2 translation via cap-dependent initiation, supported by CCLE correlation, immunoblots, luciferase assays, and siRNA knockdown.

Discussion

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Cite This Study

Manara et al. (2025) studied this question.

synapsesocial.com/papers/68de68f683cbc991d0a21cb1 https://doi.org/10.1158/0008-5472.30255182

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Supplementary Figure S5 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S5 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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